Peroxisomal stress responses
Peroxisomes are vital organelles, involved in various metabolic processes. Despite their critical roles, our understanding of how cells respond to peroxisomal stress remains limited. Our primary goal is to address these gaps and shed light on the quality control pathways activated during peroxisome dysfunction. Through the development of temperature-sensitive in vivo worm models for peroxisome biogenesis disorders and tissue-specific degron-based knockdowns, we aim to regulate peroxisome function spatially and temporally. This approach provides a robust platform for a comprehensive exploration of nematode responses during peroxisome dysfunction and recovery. Additionally, we utilize mammalian cell culture techniques and cells obtained from patients with peroxisome biogenesis disorders to conduct a thorough characterization of peroxisome stress responses.
